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In addition, it has a better affinity for the receptor, induces tumor shrinkage in xenograft versions , and does not have any known agonistic effects. On the basis of these findings, a dose of enzalutamide was determined for further research.13 In our stage 3 trial, we evaluated whether enzalutamide would prolong life in men with progressive castration-resistant prostate cancer after chemotherapy. The look incorporated the suggestions of the Prostate Malignancy Clinical Trials Working Group 2 14 in order to avoid premature study-drug discontinuation and to help address previously identified difficulties in assessing outcomes in scientific trials involving men with prostate cancer.