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The ISUIA findings represent the natural history of unruptured aneurysms in white populations .5 Study of the similarities and distinctions in natural history between these two cohorts should yield valuable information regarding the natural course of unruptured aneurysms. The real reason for the difference in the risk of rupture between our cohort and the ISUIA cohort could be multifactorial rather than just genetic. The natural span of unruptured cerebral aneurysms depends upon the size, specific location, and the shape of individual aneurysms.. The UCAS Japan Investigators: The Natural Course of Unruptured Cerebral Aneurysms in a Japanese Cohort Although incidentally uncovered cerebral aneurysms are common,1 the management of the lesions has been controversial,2-6 and the amount of individuals undergoing repair has been increasing.7 Previous studies have shown that aneurysms smaller sized than 5 or 7 mm in the biggest dimension rarely rupture and that aneurysms in the posterior circulation have a greater tendency to rupture than perform those in the anterior circulation.5,8 To look for the most appropriate treatment for individual sufferers, we need to possess a better understanding of the chance of rupture of cerebral aneurysms.