A significant number of total mutations had been found in patients with no personal or genealogy of cancer associated with that specific gene, suggesting panel testing identifies genetic mutations not really apparent from personal and family history only. Additionally, deleterious mutations had been found in patients of all ancestries, indicating that the myRisk Hereditary Cancer test can increase mutation detection across ethnic populations. These findings may benefit patients having deleterious mutations in genes for which testing was not accessible previously, and/or whose personal/family histories do not fit with a single cancer syndrome unambiguously.Recruitment difficulties avoided the attainment of our first goal of enrolling 2000 males. We revised our sample based on estimates that 740 guys enrolled over an interval of 7 years, with yet another 8 years of follow-up, would provide 91 percent capacity to detect a 25 percent relative decrease in all-trigger mortality, assuming a median survival of 10 years. The safety and data monitoring board reviewed and approved this revision. For evaluation of the secondary end stage , a survival evaluation was performed where the data from surviving patients were censored at the end of the study and the data from patients who died from causes other than prostate cancer were censored at the day of death from that other trigger.11 We analyzed loss of life from any cause, death from prostate cancer , and bone metastases.