In a study report appearing in the September 2013 problem of The FASEB Journal.

Absence or presence of single protein can make cancer cells pretty much susceptible to drugs A new weakness has been discovered in cancer cellular material that could make them more susceptible to chemotherapy and additional treatments. In a study report appearing in the September 2013 problem of The FASEB Journal, scientists identify the HDAC5 proteins as being essential for the maintenance of structures, called telomeres, within malignancy cells that promote cancer cells longevity. Cancer cells with much longer telomeres tend to be resistant to therapies, while cancers cells with shorter telomeres tend to be more susceptible. By targeting the mechanism utilized by cancer cells to keep up telomeres, HDAC5, existing therapies could become a lot more effective at eradicating tumor than they are today.Found that site-specific mutagenesis that substituted alanine for arginine at position 338 resulted in a factor IX molecule with clotting activity that was three times the clotting activity in wild-type factor IX.19 This region of the protein is important for substrate binding, and changing from arginine to alanine at position 338 increases the efficiency of the binding of the substrate to the enzyme .10 Sites at which cytosines precede a guanosine in the DNA sequence are believed to be hotspots for mutations,22 and mutations in CpG dinucleotides comprise 25 percent of all mutations in hemophilia B.15 Stop-codon mutations at R338 are common in hemophilia B, but the anticipated rates of mutations due to transition at R338 are underrepresented.23 The only real missense mutation as of this position in hemophilia B is R338P.