Similar benefits had been seen in the case of exacerbations that did not require treatment with systemic corticosteroids, confirming that the effect also put on mild exacerbations. As compared with placebo, the use of fluticasone had a smaller sized overall negative influence on parents and on their quality of life, although the latter difference was little. The smaller gain in height and weight in children treated with fluticasone in comparison with those given placebo is cause for concern.38 The non-significant group difference observed after adjustment for covariates and in per-protocol analyses will not rule out a substantial effect, particularly in view of the correlation between the cumulative dose and the noticeable change in height.39 To our knowledge, weight loss is not previously reported in patients treated with inhaled corticosteroids40; in fact, the opposite would be anticipated through a systemic impact.It isn’t a weakness of will. .. AACN adds research evaluations from Cochrane Collaboration in Critical Treatment Nurse journal The American Association of Critical-Treatment Nurses adds research reviews from The Cochrane Collaboration as a normal section in its clinical practice journal, Critical Treatment Nurse. Three times a year, Critical Care Nurse will publish summaries of Cochrane Testimonials that translate valid and reliable research into implications for critical care nursing practice.