AMRI plans to close its API manufacturing unit in Holywell, U.K. AMRI announced today that it has made a decision to close its Holywell, U.K. Facility following a consultation process with employee representatives. The Holywell site provides chemical development services and little – and large scale-manufacturing services of active pharmaceutical substances and intermediates. ‘This was a difficult decision since it impacts team people who have made valuable contributions to AMRI,’ said William S.Reactogenicity of the vaccine had not been decreased with dilution and decreasing strengths of the vaccine. This scholarly study was conducted before reports of adverse events, including heart disease, were reported in February 2003 among civilian and military smallpox vaccine recipients. This enables for amplification of the current smallpox vaccine stockpile [around 85 million doses of APSV], if needed. Smallpox is an acute, contagious, and sometimes fatal disease caused by the variola virus and is usually marked by fever and a distinctive progressive pores and skin rash.