Studies were then performed within an NHP hemophilia inhibitor model, in which a HA phenotype was induced via administration of a polyclonal anti-factor VIII antibody. The anti-aspect VIII antibody treatment resulted in a sharp decrease in plasma factor VIII activity levels to significantly less than 1 percent of normal, identical to a serious hemophilia condition in the current presence of anti-element VIII inhibitors. Animals received six weekly dosages of saline or ALN-AT3 at 0.25 or 0.50 mg/kg. ALN-AT3 treated pets showed the expected degree of AT knockdown but also showed a statistically significant dose-dependent increase in thrombin generation, fully restoring this hemostatic parameter back again to normal levels. These results demonstrate that ALN-AT3 can normalize thrombin era in the lack of functional levels of element VIII and/or in the current presence of anti-factor VIII antibodies in a large animal model, providing essential proof concept for this program.And the pair returned to work.
AP: Poll displays support for health law drops with budget woes The Associated Press: Poll Shows Health Care Rules Support Dips On Spending budget Woes Amid a budget debate that will affect medical care of virtually every family, a new poll finds support for President Barack Obama’s overhaul at its lowest level since passage last year. But in a ringing protection of Obama’s policies, Tuesday for more time on medical care legislation Medicare chief Donald Berwick pleaded, and branded a leading Republican program unfair and dangerous and a kind of withholding care. The Associated Press-GfK poll demonstrated that support for Obama’s expansion of health insurance coverage has slipped to 35 %, while opposition stands at 45 % and another 17 % are neutral .