Twice in 2011, 90-year outdated evangelical minister Harold Camping predicted the end of the world predicated on his personal mathematical calculations, first on, may 21 then on October 21. Thirty years ago Nearly, Pat Robertson informed his millions of television viewers that the Second Coming would happen 1982. Doomsday predictions are not a recently available phenomenon. In 1843, a preacher from upstate New York, William Miller, persuaded over 50,000 followers that Christ would come back, bringing the final end of the world in 1843. Like Harold Camping, Miller had to revise his prediction, with his fans awaiting a re-scheduled end of the world in 1844, leading to what history books term the Great Disappointment.For the Pelvic Floor Disorders Network: Anticholinergic Therapy vs. OnabotulinumtoxinA for Urgency Urinary Incontinence Urgency urinary incontinence is characterized by unpredictable lack of urine; it is a prevalent condition occurring disproportionately in women, affecting up to 19 percent of older females in the United States. 1 Anticholinergic medications are used as the primary treatment because of this condition. A recent systematic review of trials comparing remedies for urgency bladder control problems showed that none of the six medicines evaluated was superior to another in treating the condition and that current evidence was insufficient to steer the choice among other treatments, including injections of botulinum toxin.2 OnabotulinumtoxinA works well in treating urgency bladder control problems that is resistant to anticholinergic therapy, but this treatment can result in incomplete bladder emptying, necessitating temporary bladder catheterization.3 Data comparing onabotulinumtoxinA with anticholinergic agents have already been lacking directly.